Leftose

Leftose

Manufacturer:

Kenyaku

Distributor:

Schumit
Full Prescribing Info
Contents
Egg white lysozyme chloride.
Description
LEFTOSE Tablets contain 30 mg (potency) of egg white lysozyme chloride per tablet.
Egg white lysozyme chloride is readily soluble in water, and is a basic protein composed of 129 amino acids and with the molecular weight of about 14,700.
Action
Pharmacology: Pharmacodynamics: Following actions of lysozyme have been reported: Antiviral action, antibacterial action.
Enzymatic Activity: Since the substrates of lysozyme are mucopolysaccharides, the enzyme is a kind of mucopolysaccharides and has the beta-glucosaminidase activity. The action site of lysozyme is the beta-(1-4) linkage between N-acetylmuramic acid and N-acetylglucosamine, and recent success of X-ray analysis has revealed that the active site of lysozyme is the imidazole nucleus contained in the histidine residue and that a partial active site resides in the indole nucleus in tryptophan.
Difficulty of Expectoration: LEFTOSE decomposes and dissolves mucous pus to make its discharging easy, suppresses excessive secretion of mucus, and thereby accelerates curing of the focus.
Toxicology: Toxicity: The toxicity of lysozyme chloride is so weak that LD 50 in rat is 3,550 mg/kg by intravenous administration, 5,500 mg/kg by intraperitoneal administration, and more than 20,000 mg/kg (not calculable) by oral administration. No anomalies have been observed in histological investigation after a long period of administration.
Indications/Uses
Acute and chronic paranasal sinusitis, infantile paranasal sinusitis, pharyngitis, laryngitis, stomatitis (erosion and ulcer), otitis media.
Periserotinitis, alveolar abscess, submaxillary lymphadenitis due to gram-positive bacteria.
Dosage/Direction for Use
Usually 1 tablet, 3 times daily for adults.
ATC Classification
M09AB - Enzymes ; Used in the treatment of musculo-skeletal disorders.
Presentation/Packing
Tab 30 mg (colorless, odorless, and crystalline powder) x 10 x 10's, 50 x 10's, 500's.
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