Egg white lysozyme chloride.
LEFTOSE Tablets contain 30 mg (potency) of egg white lysozyme chloride per tablet.
Egg white lysozyme chloride is readily soluble in water, and is a basic protein composed of 129 amino acids and with the molecular weight of about 14,700.
Pharmacology: Pharmacodynamics: Following actions of lysozyme have been reported: Antiviral action, antibacterial action.
Enzymatic Activity: Since the substrates of lysozyme are mucopolysaccharides, the enzyme is a kind of mucopolysaccharides and has the beta-glucosaminidase activity. The action site of lysozyme is the beta-(1-4) linkage between N-acetylmuramic acid and N-acetylglucosamine, and recent success of X-ray analysis has revealed that the active site of lysozyme is the imidazole nucleus contained in the histidine residue and that a partial active site resides in the indole nucleus in tryptophan.
Difficulty of Expectoration: LEFTOSE decomposes and dissolves mucous pus to make its discharging easy, suppresses excessive secretion of mucus, and thereby accelerates curing of the focus.
Toxicology: Toxicity: The toxicity of lysozyme chloride is so weak that LD 50 in rat is 3,550 mg/kg by intravenous administration, 5,500 mg/kg by intraperitoneal administration, and more than 20,000 mg/kg (not calculable) by oral administration. No anomalies have been observed in histological investigation after a long period of administration.
Acute and chronic paranasal sinusitis, infantile paranasal sinusitis, pharyngitis, laryngitis, stomatitis (erosion and ulcer), otitis media.
Periserotinitis, alveolar abscess, submaxillary lymphadenitis due to gram-positive bacteria.
Usually 1 tablet, 3 times daily for adults.
M09AB - Enzymes ; Used in the treatment of musculo-skeletal disorders.
Tab 30 mg (colorless, odorless, and crystalline powder) x 10 x 10's, 50 x 10's, 500's.