Adjuvant treatment of postmenopausal women w/ hormone receptor positive early breast cancer. Extended adjuvant treatment of early breast cancer in postmenopausal women who have received prior standard adjuvant tamoxifen therapy. 1st-line treatment in postmenopausal women w/ hormone-dependent advanced breast cancer. Treatment of advanced breast cancer in women w/ natural or artificially-induced postmenopausal status, who have previously been treated w/ antioestrogens.
Dosage/Direction for Use
Adult 2.5 mg once daily. In adjuvant & extended adjuvant setting, treatment should continue for 5 yr or until tumor relapse occurs. In metastatic disease, continue until tumor progression is evident.
For postmenopausal women only. Close supervision for renal (CrCl <10 mL/min) & hepatic (Child-Pugh C) impairment. May increase total serum cholesterol & decrease in bone mineral density. May impair ability to drive or operate machinery.