Leucovorin Calcium Injection Fresenius Kabi

Leucovorin Calcium Injection Fresenius Kabi

calcium folinate

Manufacturer:

Fresenius Kabi

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Leucovorin Ca
Indications/Uses
Leucovorin rescue after high-dose methotrexate (MTX) therapy & in overdosage of folic acid antagonists.
Dosage/Direction for Use
Impaired MTX elimination or inadvertent overdosage 10 mg/m2 body surface area IV or IM 6 hrly until serum methotrexate level <108 M. Max: 100 mg/m2 IV 3 hrly. Leucovorin rescue after high-dose MTX therapy Based on an IV MTX dose of 12-15 g/m2, initiate leucovorin rescue at a dose of 15 mg 6 hrly for 10 doses. Continue until MTX level is <5 x 108 M.
Contraindications
Pernicious anaemia & other megaloblastic anaemias secondary to vit B12 deficiency.
Special Precautions
Elderly or debilitated patients. Pregnancy & lactation.
Adverse Reactions
Allergic sensitization, including anaphylaxis & urticaria.
Drug Interactions
Phenobarb, phenytoin, primidone.
ATC Classification
V03AF03 - calcium folinate ; Belongs to the class of detoxifying agents used in antineoplastic treatment.
Presentation/Packing
Form
Leucovorin Calcium Injection Fresenius Kabi inj 50 mg/5 mL
Packing/Price
1's
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