T. O. Chemicals


T. O. Chemicals
Concise Prescribing Info
Levocetirizine diHCl
Seasonal, perennial & persistent allergic rhinitis; chronic urticarial.
Dosage/Direction for Use
Adult & childn ≥12 yr Allergic rhinitis & chronic urticarial 2.5-5 mg once daily. Childn 6-11 yr 2.5 mg once daily in the evening. Renal impairment: Adult & childn ≥12 yr CrCl 50-80 mL/min 2.5 mg once daily, CrCl 30-50 mL/min 2.5 mg every other day, CrCl 10-30 mL/min 2.5 mg twice wkly (once every 3-4 days).
May be taken with or without food.
Hypersensitivity to levocetirizine or cetirizine. Adult & childn ≥12 yr w/ end-stage renal disease (CrCl <10 mL/min) or undergoing hemodialysis. Ped patients 6 mth to 11 yr w/ renal impairment.
Special Precautions
Renal & hepatic impairment. Predisposing factors of urinary retention eg, spinal cord lesion & prostatic hyperplasia. Concomitant use w/ alcohol or other CNS depressants eg, benzodiazepines or antidepressants. May cause blurred vision, confusion & dysuria. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Do not drive, operate machinery or work at height during therapy. Pregnancy (1st trimester) & lactation. Childn <6 yr.
Adverse Reactions
Somnolence, fatigue, headache, asthenia, sleep disorder; dry mouth, diarrhea, constipation, vomiting; nasopharyngitis, pharyngitis, cough; otitis media; pyrexia, epistaxis.
Drug Interactions
Possible additive adverse CNS effects w/ CNS depressants eg, alcohol. Increased AUC & t½ w/ cetirizine & ritonavir. Decrease clearance of cetirizine.
ATC Classification
R06AE09 - levocetirizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.
Levtrizin FC tab 5 mg
1 × 10's;10 × 10's
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