In patients who are intravascularly volume-depleted (e.g. those treated with high-dose diuretics), symptomatic hypotension may occur. A lower starting dose should be used.
Use with caution in patients with pre-existing renal insufficiency.
Low dose of Losartan potassium should be administered in patients with hepatic impairment due to a significant increase of plasma concentrations of Losartan potassium.