Increased risk of paracetamol-induced hepatotoxicity w/ alcohol. Increased drug conversion to hepatotoxic metabolites w/ anticonvulsants (eg, phenytoin, barbiturates, carbamazepine). Increased risk of hepatotoxicity w/ INH. Increase risk of adverse effects of coumarin & indandione derivative anticoagulant (in large paracetamol doses). Possible severe hypothermia w/ phenothiazines. Additive CNS depression may occur w/ CNS depressants including barbiturates, tranquilizers & alcohol.