Treatment & prevention of postmenopausal osteoporosis, increase bone mass in men w/ osteoporosis, glucocorticoid-induced osteoporosis in men & women.
Dosage/Direction for Use
1 tab once wkly.
Should be taken on an empty stomach: Take at least 30 min before the 1st food/drink/medication of the day w/ a full glass of plain water & remain in sitting/upright position for at least 30 min. Swallow whole, do not chew/crush.
Hypersensitivity. Abnormalities of the oesophagus & factors which delay stricture or achalasia. Inability to stand or sit up right for at least 30 min. Hypocalcaemia.
Active GI problems or recent history of major GI disease. Discontinue if symptoms of oesophageal irritation develops. Osteonecrosis of the jaw associated w/ tooth extraction &/or local infection in patients w/ cancer & osteoporosis receiving IV & oral bisphosphonates, respectively. Dental exam should be considered prior to treatment. Dental surgery. Renal impairment (CrCl <35 mL/min). Correct hypocalcemia prior to initial therapy. Ensure adequate Ca & vit D intake in patients receiving glucocorticoids. Pregnancy & lactation. Childn.