Hypersensitivity to cefditoren or other cephalosporins. Patients w/ carnitine deficiency or inborn errors of metabolism; milk protein hypersensitivity (not lactose intolerance).
Avoid in patients w/ history of hypersensitivity reaction to penicillins. Carefully monitor patients for superinfection during therapy. Consider Clostridium difficile-associated diarrhea during or after therapy. Should not be used in patients w/ carnitine deficiency or inborn errors of metabolism; increased risk of reduced serum carnitined conc during therapy. Monitor prothrombin time & administer vit K in patients at risk for reduced prothrombin activity (eg, patients w/ renal or hepatic impairment, or poor nutritional status, patients receiving prolonged antimicrobial therapy or previously stabilizes on anticoagulant therapy). Pregnancy & lactation. Childn <12 yr. Elderly (w/ impaired renal function).
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