Meithromax

Meithromax

azithromycin

Manufacturer:

Meiji

Distributor:

DKSH
Concise Prescribing Info
Contents
Azithromycin
Indications/Uses
Lower (eg, bronchitis & pneumonia) & upper (eg, sinusitis & pharyngitis/tonsillitis) resp tract infections, odontostomatological infections in skin & soft tissue infections, & acute otitis media. Uncomplicated genital infections due to Chlamydia trachomatis & nonmultiresistant Neisseria gonorrhoea, chancroid due to H. ducreyi. Alone or in combination w/ rifabutin for prophylaxis against Mycobacterium avium-intracellular complex (MAC) infection in patients w/ advance HIV. In combination w/ ethambutol for treatment of disseminated MAC (DMAC) infection in patients w/ advance HIV infection.
Dosage/Direction for Use
Cap Adult STD caused by C. trachomatis, H. ducreyi or susceptible N. gonorrhoea 1,000 mg single dose. Prophylaxis against MAC infections (in HIV patient) 1,200 mg once/wk. DMAC infections (in advanced HIV infection patient) 600 mg once daily in combination w/ other antimycobacterial agents eg, ethambutol. Childn Max total dose: 1,500 mg. 30 mg/kg given as single daily dose of 10 mg/kg for 3 days w/ the exception of Strep pharyngitis treatment. Streptococcal pharyngitis 10 or 20 mg/kg as single daily dose for 3 days. Max: 500 mg daily. Oral susp Acute otitis media 10 mg/kg/day as single daily dose for 3 days. 30 mg/kg total treatment dose: 36-45 kg 400 mg (10 mL) once daily on days 1-3, 26-35 kg 300 mg (7.5 mL) once daily on days 1-3, 15-25 kg 200 mg (5 mL) once daily on days 1-3, <15 kg 10 mg/kg once daily on days 1-3.
Administration
Cap: Should be taken on an empty stomach: Take at least 1 hr before or 2 hr after meals or Al- & Mg-containing antacids.|Powd for oral susp: May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Contraindications
History of hypersensitivity to macrolides.
Special Precautions
Significant hepatic disease, severe renal impairment (GFR <10 mL/min). Superinfection. Concomitant use w/ ergot derivatives. Pregnancy & lactation.
Adverse Reactions
Nausea, vomiting, diarrhea, loose stools, abdominal discomfort (pain/cramps) & flatulence; transient episodes of mild neutropenia; abnormal liver function; rash & angioedema; hearing loss, deafness &/or tinnitus.
Drug Interactions
May increase levels of digoxin. Coumarin-type anticoagulants. Elevate Cmax & AUC0-5 of cyclosporin. May affect plasma pharmacokinetics or urinary excretion of zidovudine or its glucuronide metabolite. Possible risk of ergotism w/ ergot derivatives. Antacids.
MIMS Class
ATC Classification
J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Presentation/Packing
Form
Meithromax powd for oral susp 200 mg/5mL
Packing/Price
1's
Form
Meithromax cap 250 mg
Packing/Price
6's
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