COCs should not be used in the presence of any of the following conditions. Should any of the conditions appear for the 1st time during COC use, the product should be stopped immediately:
Thrombosis (venous or arterial) present or in history (eg, deep venous thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular accident).
Presence or history of prodromi of a thrombosis (eg, transient ischemic attack, angina pectoris).
Diabetes mellitus with vascular involvement.
The presence of a severe or multiple risk factor(s) for venous or arterial thrombosis may also constitute a contraindication (see Warnings).
Presence or history of severe hepatic disease as long as liver function values have not returned to normal.
Presence or history of liver tumors (benign or malignant).
Known or suspected malignant conditions of the genital organs or the breasts, if sex steroid-influenced.
Undiagnosed vaginal bleeding.
Known or suspected pregnancy.
Hypersensitivity to any of the components of Meliane/Meliane ED.