Unless prescribed otherwise, doses are as follows:
Sterility in Females: The dosage of HMG for the induction of follicle growth in normo- or hypogonadotrophic women varies according to the individual.
The amount depends on ovarian reaction and should be checked by ultrasound examinations of the ovaries and measuring estradiol levels. If the HMG dosage is too high for the treated individual, multiple uni- and bilateral follicle growth can occur.
HMG is administered IM or SC and in general, the therapy is begun with a daily dosage corresponding to 75-150 iu FSH + 75-150 iu LH. If the ovaries do not respond, the dosage can slowly be increased until a rise in estradiol secretion and follicle growth is evident. Treatment with the same dosage of HMG continues until the preovulatory estradiol serum level is attained. If the level rises too quickly, the dosage should be reduced. To induce ovulation, hCG 5000 or 10,000 iu are injected IM 1-2 days after the last HMG administration.
Note: After administering a HMG dosage which is too high for the corresponding individual, a subsequent hCG administration can cause an unintentional hyperstimulation of the ovaries.
Sterility in Males: Initially, 3 x 1000 and 3000 iu hCG a week are administered until a normal testosterone serum level is reached. Then, an additional dose of HMG 3 x (75-150 iu FSH + 75-150 iu LH)/week is administered IM for a few months.
Administration: For IM or SC injection following dissolution in the solvent attached.