hCG should not be administered to induce ovulation in females whose ovaries have unintentionally been hyperstimulated.
When treating sterile women, ovarian activity should be checked (ultrasound and estradiol levels in serum response) prior to HMG administration. During treatment, these tests should be carried out every 1-2 days until stimulation occurs. Ovarian reaction can also be measured using a cervix index. Close supervision is imperative during treatment. Treatment should be immediately discontinued if unintentional hyperstimulation occurs.
Further remarks concerning the steps to be taken when ovarian hyperstimulation has occurred can be found under Actions.