Treatment of type 2 or maturity onset DM not responsive to diet alone or diet plus treatment w/ sulphonylurea.
Dosage/Direction for Use
Metformin 500 Initially 1 tab bid, gradually increased to 1 tab wkly. Metformin 850 1 tab daily, gradually increased to 2 tab every 2 wk. Max: 2.5 g daily in 3 divided doses.
Should be taken with food.
Impaired hepatic or renal function, CV collapse, CHF, acute MI or conditions leading to hypotension or hypoxaemia. Patients w/ DM complicated by acidosis, infection or gangrene. Surgery. Pregnancy.
Lactic acidosis. Discontinue 48 hr before elective surgery w/ general anesth or prior to or at the time of administration of iodinated contrast agent. Renal impairment; determine serum creatinine levels before initiating treatment & monitor regularly. Elderly. Childn 10-12 yr. Lactation.