Methotrexat-Ebewe

Methotrexat-Ebewe

methotrexate

Manufacturer:

Sandoz

Distributor:

Zuellig Pharma

Marketer:

Novartis
Concise Prescribing Info
Contents
Methotrexate
Indications/Uses
Acute lymphatic leukaemia, mammary, ovarian & bronchial carcinoma, chorion epithelioma, tumours of head & neck, testicular tumours, osteosarcoma, leukaemic meningo-encephalomyelopathy, refractory psoriasis vulgaris. Autoimmune diseases.
Dosage/Direction for Use
Tab Malignant tumors & haemoblastoses Individualized dosage. Psoriasis, psoriatic arthritis & autoimmunopathies Wkly dosage: 10-25 mg. Start w/ 2.5-7.5 mg, increased to 25 mg wkly. Divided oral dosage: 2.5 mg 12 hrly for 3 doses/wk. Vial Dilute to a soln containing 1-2% methotrexate. Dosage individually adapted to each patient. By IV infusion.
Contraindications
Pregnancy. Diseases of the hematopoietic system. Recent operation wounds.
Special Precautions
Infection, peptic ulcer, ulcerative colitis, debility & extreme youth & old age, liver & kidney dysfunction.
Adverse Reactions
Ulcerative stomatitis, leukopenia, thrombopenia, nausea & abdominal distress.
Drug Interactions
Folic acid. Salicylates, phenylbutazone, phenytoin, barbiturates, sulfonamides, corticosteroids, tetracyclines, chloramphenicol, PABA, p-aminohippuric acid or probenecid.
ATC Classification
L01BA01 - methotrexate ; Belongs to the class of antimetabolites, folic acid analogues. Used in the treatment of cancer.
Presentation/Packing
Form
Methotrexat-Ebewe infusion 5000 mg/50 mL
Packing/Price
1's
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