Community Pharm PCL


Community Pharm PCL
Concise Prescribing Info
Acute bacterial exacerbations of chronic bronchitis; acute pelvic inflammatory disease (including severe infection); acute uncomplicated uretheral & cervical gonorrhea. Community-aquired pneumonia. Complicated UTI. Urethra & cervix infections; nongonococcal urethritis & cervicitis. Prostatitis; uncomplicated cystitis & skin & skin structure infections.
Dosage/Direction for Use
Adult Usual dosage: 200-400 mg every 12 hr. Acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, uncomplicated skin & skin structure infections 400 mg bid for 10 days. Acute pelvic inflammatory disease 400 mg bid for 10-14 days. Acute, uncomplicated urethral & cervical gonorrhea 400 mg single dose. Complicated UTI 200 mg bid for 10 days. Mixed infections of the urethra & cervix due to C. trachomatis & N. gonorrhoeae & nongonococcal urethritis & cervicitis due to C. trachomatis 300 mg bid for 7 days. Prostatitis due to E. coli 300 mg bid for 6 wk. Uncomplicated cystitis due to E. coli or K. pneumonia 200 mg bid for 3 days. Uncomplicated cystitis due to other approved pathogens 200 mg bid for 7 days.
May be taken with or without food: Avoid antacids or supplements containing Fe or Zn w/in 2 hr before or after ofloxacin. Ensure adequate hydration.
Hypersensitivity to ofloxacin or other quinolones.
Special Precautions
May increase risk of tendinitis or tendon rupture; discontinue if pain, swelling, inflammation or rupture of tendon occurs. Patients w/ known or suspected CNS disorder that predispose to seizures or lower the seizure threshold. Avoid excessive exposure to sunlight or artificial UV light. Discontinue if phototoxicity occurs. History of QT interval prolongation. Hepatic or renal impairment. Pregnancy & lactation.
Adverse Reactions
Hyperglycemia, hypoglycemia. External genital pruritus in women. Chest pain; sleep disorders, nervousness; vag discharge; dysgeusia; decreased appetite, GI distress, pharyngitis, trunk pain.
Drug Interactions
Absorption reduced by antacids (Mg, Al or Ca-containing). May increase risk of prolonged QT interval w/ antiarrhythmic agents class IA (eg, quinidine, procainamide) or class III (eg, amiodarone, sotalol). May increase risk of severe tendon disorders (eg, tendinitis; tendon rupture) w/ corticosteroids. May increase risk of CNS stimulation w/ NSAIDs. May increase serum conc & AUC of tizanidine. May increase prothrombin time w/ coumarin. May increase & prolong serum conc & increase risk of adverse effects of theophylline.
MIMS Class
ATC Classification
J01MA01 - ofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Mifloxin FC tab 200 mg
10 × 10's
Mifloxin film-coated tab 100 mg
25 × 10's
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