Mifloxin

Mifloxin Drug Interactions

ofloxacin

Manufacturer:

Community Pharm PCL

Distributor:

Community Pharm PCL
Full Prescribing Info
Drug Interactions
Concomitant administration of ofloxacin and antacids (magnesium, aluminium or calcium-containing) may decrease absorption of oral quinolones resulting in decreased serum and urine concentrations of the anti-infectives.
Concomitant use of ofloxacin and antiarrhythmic agents class IA (e.g., quinidine, procainamide) or class III (e.g., amiodarone, sotalol) may increase the risk of QT interval prolongation.
Coadministration of ofloxacin and corticosteroids may increase the risk of severe tendon disorders (e.g., tendinitis, tendon rupture), especially in geriatric patients older than 60 years of age.
Concomitant use of ciprofloxacin and nonsteroidal anti-inflamatory agents could increase the risk of CNS stimulation (e.g., seizure).
Concomitant use of ciprofloxacin and tizanidine may increase serum concentrations and AUC of tizanidine and potentiated the hypotensive and sedative effects of the drug.
Concomitant administration of ofloxacin and coumarin anticoagulant may increase prothrombin times.
Concomitant use of ofloxacin and theophylline may result in higher and prolonged serum theophylline concentrations and may increase the risk of theophylline-related adverse effects.
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