Mifloxin Mechanism of Action



Community Pharm PCL


Community Pharm PCL
Full Prescribing Info
Pharmacology: Pharmacodynamics: Mechanism of Action: Ofloxacin usually is bactericidal in action. Ofloxacin inhibits DNA synthesis in susceptible organisms via inhibition of the enzymatic activities of 2 members of the DNA topoisomerase class of enzymes, DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
Pharmacokinetics: Ofloxacin is rapidly and almost completely absorbed from the GI tract following oral administration. The drug doses not undergo appreciable first-pass metabolism. The oral bioavailability of ofloxacin is 85-100% in healthy, fasting adults and peak serum concentrations of the drug generally are attained within 0.5-2 hours. Ofloxacin is widely distributed into body tissues and fluids following oral administration. The apparent volume of distribution of ofloxacin averages 1-2.5 L/kg. Ofloxacin is 20-32% bound to serum proteins; the drug is bound mainly to albumin. Ofloxacin crosses the placenta and is distributed into cord blood and amniotic fluid. The drug is distributed into milk following oral administration. The elimination half-life of ofloxacin is 4-8 hours. Elimination is mainly by renal excretion; 4% to 8% is excreted in the feces. Renal clearance of ofloxacin average 133-200 mL/min in adults with normal renal function.
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