Infections and infestations:
Very common: Nasopharyngitis. Rare: Infection.
Blood and lymphatic system disorders:
Uncommon: thrombocytopenia, leukopenia. Rare: pancytopenia, neutropenia, agranulocytosis.
Immune system disorders:
Rare: Drug reaction with eosinophilia and systemic symptoms (DRESS).
Metabolism and nutrition disorders:
Common: Anorexia. Uncommon: weight decreased, weight increase. Rare: hyponatremia.
Common: depression, hostility/aggression, anxiety, insomnia, nervousness/irritability. Uncommon: suicide attempt, suicidal ideation, confusional state. Rare: completed suicide.
Nervous system disorders:
Very common: somnolence, headache. Common: convulsion, dizziness, lethargy, tremor. Uncommon: amnesia, ataxia, paresthesia, disturbance in attention. Rare: choreoathetosis, dyskinesia, hyperkinesia.
Uncommon: diplopia, vision blurred.
Ear and labyrinth disorders:
Respiratory, thoracic and mediastinal disorders:
Common: abdominal pain, diarrhea, dyspepsia, vomiting, nausea. Rare: pancreatitis.
Uncommon: liver function test abnormal. Rare: hepatic failure, hepatitis.
Skin and subcutaneous tissue disorders:
Common: Rash. Uncommon: alopecia, eczema, pruritus. Rare: Toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme.
Musculoskeletal and connective tissue disorders:
Uncommon: muscular weakness, myalgia.
General disorders and administration site conditions:
Injury, poisoning and procedural complications:
The risk of anorexia is higher when levetiracetam is coadministered with topiramate. In several cases of alopecia, recovery was observed when levetiracetam was discontinued. Bone marrow suppression was identified in some of the cases of pancytopenia.