Common: Endocrine metabolic: Hypokalemia (1%).
Gastrointestinal: Abdominal pain (2%), Constipation (2%), Diarrhea (5%), Nausea (7%), Vomiting (2%).
Hepatic: ALT/SGPT level abnormal (1%)
Neurologic: Dizziness (3%), Headache (4%)
Ophthalmic: Dry eyes (Ophthalmic, 1% to 6%), Keratitis (Ophthalmic, 1% to 6%), Pain in eye (Ophthalmic, 1% to 6%), Reduced visual acuity (Ophthalmic, 1% to 6%)
Serious: Cardiovascular: Aortic aneurysm, or dissection, Prolonged QT interval (Oral/IV, 0.1% to less than 1%), Torsades de pointes.
Dermatologic: Rash (Oral/IV, 0.1% to less than 1%), Stevens-Johnson syndrome, Toxic epidermal necrolysis.
Endocrine metabolic: Hyperglycemia (Oral/IV, 0.1% to less than 1%), Hypoglycemia.
Gastrointestinal: Clostridium difficile diarrhea.
Hematologic: Agranulocytosis, Aplastic anemia, Hemolytic anemia, Pancytopenia, Thrombocytopenia (Oral/IV, 0.1% to less than 1%)
Hepatic: Hepatic necrosis, Hepatitis, Liver failure.
Immunologic: Anaphylactoid reaction, Hypersensitivity reaction.
Musculoskeletal: Myasthenia gravis, Exacerbation, Rupture of tendon, Tendinitis.
Neurologic: Guillain-Barre syndrome, Peripheral neuropathy, Pseudotumor cerebri, Raised intracranial pressure, Seizure.
Ophthalmic: Retinal detachment Renal: Renal failure (0.1% to less than 1%).
Respiratory: Extrinsic allergic alveolitis.
Other: Serum sickness due to drug.