Movelox Injection 400 mg should be infused IV over 60 minutes, rapid IV infusion of the drug should be avoided.
Commercial available injection for IV infusion containing 400 mg of moxifloxacin in 0.8% sodium chloride injection may be used without further dilution.
When IV moxifloxacin therapy is used initially, therapy may be changed to oral moxifloxacin (when appropriate) using the same dosage to complete therapy. (See Table 1.)
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Special populations: Dosage adjustment is not necessary in patients with mild to moderate hepatic insufficiency (Child Pugh class A and B). The pharmacokinetics of moxifloxacin have not been evaluated in patients with severe hepatic insufficiency (Child Pugh class C).
No adjustment of dosage is required in patients with renal impairment, including those haemodialysis or continuous ambulatory peritoneal dialysis (CAPD).
Dosage adjustments based solely on age are not necessary for geriatric patients 65 years of age and older.
Mode of Administration: Moxifloxacin is administered by IV infusion. The drug should not be given IM or by intrathecal, intraperitoneal, or subcutaneous administration.
Patients receiving IV moxifloxacin should be well hydrated and should be instructed to drink fluids liberally.
This drug may be administrated singly or with the following solutions. It is stable over 24 hours when this medicinal product is mixed with following solutions.
Sterile Water for Injection; Sodium Chloride Injection; 5% Dextrose Injection; Lactated Ringer's for Injection.