2 to 10%: Central nervous system:
Headache, dizziness, insomnia.
Endocrine & metabolic:
Chloride increased, glucose decreased, ionized calcium increased.
Nausea, diarrhea, amylase decreased, constipation, vomiting, abdominal pain.
Decreased serum levels of basophils, eosinophils, hemoglobin, PT, RBC, and neutrophils, increased serum levels of MCH, neutrophils, PT, and WBC.
0.1 to <2%: Cardiovascular:
Angina, atrial fibrillation, bradycardia, cardiac arrest, edema, heart failure, hypertension, hypotension, palpitation, peripheral edema, QTc prolongation, syncope, tachycardia.
Central nervous system:
Fever, agitation, anxiety, chills, confusion, depression, disorientation, fatigue, hallucinations, hypoesthesia, lethargy, malaise, nervousness, pain, restlessness, somnolence, vertigo.
Allergic dermatitis, erythema, hyperhidrosis, pruritus, rash, urticarial.
Endocrine & metabolic:
Hypokalemia, dehydration, hyperglycemia, hyperlipidemia, triglycerides increased, uric acid increased.
Dyspepsia, abdominal discomfort, abdominal distension, amylase increased, anorexia, appetite decreased, flatulence, gastritis, gastroenteritis, gastroesophageal reflux disease, lactic dehydrogenase increased, lipase increased, taste perversion, xerostomia.
Dysuria, vaginitis, vulvovaginal candidiasis, vulvovaginal mycotic infection, vulvovaginal pruritus.
Anemia, eosinophilia, hematocrit decreased, leukocytosis, leukopenia, aPTT increased, thrombocytothemia, thrombocytopenia.
ALT increased, AST increased, alkaline phosphatase increased, GGTP increased, liver function test abnormal.
Neuromuscular & skeletal:
Arthralgia, back pain, chest pain (noncardiac), facial pain, limb pain, muscle spasms, musculoskeletal pain, myalgia, paresthesia, tremor, weakness.
BUN increased, creatinine increased, renal failure.
Asthma, bronchospasm, dyspnea, wheezing.
Allergic reaction, candidiasis, fungal infection, night sweats, oral candidiasis.
Agranulocytosis, anaphylactic reaction, anaphylactic shock, angioedema, aplastic anemia, C. difficile
-positive diarrhea, cholestasis, deafness (reversible), ECG abnormalities, hearing impairment, hemolytic anemia, hepatic failure, hepatic necrosis, hepatitis, hypersensitivity reactions, INR decreased, interstitial nephritis, intracranial pressure increased, jaundice (cholestatic), myasthenia gravis exacerbation, nightmares, pancytopenia, peripheral neuropathy, photosensitivity/toxicity, pneumonitis (allergic), polyneuropathy, pseudomembranous colitis, pseudotumor cerebri, psychotic reaction, renal dysfunction, seizure, Stevens-Johnson syndrome, suicidal behavior/ideation, tendonitis, tendon rupture, thrombotic thrombocytopenic purpura, toxic epidermal necrolysis, ventricular tachyarrhythmias (including torsade de pointes and cardiac arrest [usually in patients with concurrent, severe proarrhythmic conditions]), vasculitis, vision loss (transient).