Bayer HealthCare Pharma


Concise Prescribing Info
Induction of termination of pregnancy (maternal or fetal indication); induction of labour in the case of fetal death in utero. Treatment of postpartum atonic hemorrhage.
Dosage/Direction for Use
100 mcg/hr IV infusion for up to 10 hr. Max: 500 mcg/hr. Max total dose: 1,500 mcg/24 hr. May be repeated after 12-24 hr if purpose is not achieved. Postpartum atonic hemorrhage 100 mcg/hr. Max: 500 mcg IV infusion. Maintenance: 100 mcg/hr. Max total dose: 1,500 mcg/24 hr.
Bronchial asthma, spastic bronchitis; preexisting heart damage (even w/o signs of decompensation), case history of vascular diseases, particularly of the coronary vessels, severe HTN; severe liver or kidney disorders, decompensated diabetes; cerebral convulsions; glaucoma; thyrotoxicosis; acute gynecological infections, ulcerous colitis; acute gastric ulcer, sickle cell anemia, thalassemia; general serious diseases; previous uterine surgery. Induction of labour in the case of a viable child.
Special Precautions
Existing CV risk factors, age. Avoid intra-arterial administration. Do not inj as a bolus or as an intracervical/ intramyometrial inj.
Adverse Reactions
Nausea, vomiting, epigastric & mesogastric spasms, occasional diarrhea, drowsiness, headache, bronchoconstrictor reactions, increases of pressure in the pulmonary circulation, bradycardia or decrease in BP, myocardial ischaemia, disturbances of water & electrolyte excretion. Increased sensitivity of the myometrium to prostaglandins & isolated cases of uterine rupture.
Drug Interactions
Co-administration w/ oxytocin (except in postpartum atonic haemorrhage). NSAIDs & other prostaglandins.
ATC Classification
G02AD05 - sulprostone ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
Nalador infusion 500 mcg
3 × 1's
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