Natrilix SR

Natrilix SR





Concise Prescribing Info
Essential HTN.
Dosage/Direction for Use
1 tab daily.
Should be taken with food: Swallow whole, do not chew/crush.
Hypersensitivity to indapamide or to other sulfonamides; severe renal failure, hepatic encephalopathy or severe impairment of liver function, hypokalemia.
Special Precautions
Discontinue treatment if hepatic encephalopathy & photosensitivity occurs. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Measure Na & K levels before & during treatment. Hyponatraemia w/ hypovolaemia may be responsible for dehydration & orthostatic hypotension. Concomitant loss of Cl-ions may lead to secondary compensatory metabolic alkalosis. High risk of hypokalemia in elderly, malnourished &/or polymedicated, cirrhotic patients w/ oedema & ascites, patients w/ CAD, cardiac failure & long QT interval; measure plasma K 1 wk after start of treatment & frequently thereafter. Discontinue treatment before investigating parathyroid function. Increased tendency to gout attacks or hyperuricemia. Preexisting renal insufficiency may worsen at start of treatment. Monitor blood glucose in the case of hypokalemia especially for diabetic patients. May cause positive doping tests in athletes. May affect the ability to drive & operate machinery. Pregnancy & lactation.
Adverse Reactions
Hypersensitivity reactions, maculopapular rashes, vomiting, purpura, vertigo, fatigue, headache, paresthesia, nausea, constipation, dry mouth, agranulocytosis, aplastic anaemia, haemolytic anaemia, leucopenia, thrombocytopenia, hypercalcaemia, arrhythmia, hypotension, pancreatitis, abnormal hepatic function, angioedema, urticaria, toxic epidermic necrolysis, Stevens-Johnson syndrome, renal failure, hypokalaemia, hyponatraemia, syncope, myopia, blurred vision, visual impairment, Torsade de Pointes (potentially fatal), hepatic encephalopathy, hepatitis, possible worsening of preexisting acute disseminated lupus erythematosus, photosensitivity reactions, ECG QT prolonged, increased blood glucose & blood uric acid, elevated liver enzyme levels.
Drug Interactions
Lithium, Torsades de Pointes-inducing drugs, NSAIDs (systemic route) including COX-2 selective inhibitors & high dose salicylic acid (≥3 g/day) in dehydrated patients, ACE inhibitors, other compd causing hypokalaemia, baclofen, digitalis prep, K-sparing diuretics, metformin, iodinated contrast media, imipramine-like antidepressants, neuroleptics, Ca-salts, ciclosporin, tacrolimus, corticosteroids, tetracosactide (systemic route).
MIMS Class
ATC Classification
C03BA11 - indapamide ; Belongs to the class of low-ceiling sulfonamide diuretics.
Natrilix SR tab 1.5 mg
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