As single agent: 1st 3 administrations of 60 mg/m2
BSA once a wk as a single administration. Beyond the 3rd administration, increase to 80 mg/m2
once a wk in a single administration. In combination: Adapted to treatment protocol. Max total dose: 120 mg/wk (60 mg/m2
dose) or 160 mg/wk (80 mg/m2
wkly as single agent. In combination chemotherapy, the dose may be the same & the frequency of administration reduced ie, day 1 & 8 or day 1 & 5 every 3 wk.