Neurontin

Neurontin

gabapentin

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Gabapentin
Indications/Uses
Monotherapy in treatment of partial seizures w/ & w/o secondary generalization in adults & childn ≥12 yr. Adjunctive therapy in treatment of partial seizures w/ & w/o secondary generalization in adults & childn ≥3 yr. Neuropathic pain in adults ≥18 yr.
Dosage/Direction for Use
Epilepsy Adult & ped patients >12 yr 900-3,600 mg/day. Initially 300 mg tid on Day 1 or titrate dose to 300 mg once daily on Day 1, 300 mg bid on Day 2 & 300 mg tid on Day 3. Max: 3,600 mg/day. Max time interval: ≤12 hr. Ped patients 3-12 yr Initially 10-15 mg/kg/day in equally divided doses for approx 3 days, ≥5 yr 25-35 mg/kg/day in equally divided doses tid, 3 to <5 yr 40 mg/kg/day in equally divided doses tid. Max time interval: ≤12 hr. Neuropathic pain Adult Initially 900 mg/day given as 3 divided doses. Dose may be increased if necessary. Should be initiated by titrating dose to 300 mg once daily on Day 1, 300 mg bid on Day 2, & 300 mg tid on Day 3. Max dose: 3,600 mg/day. Epilepsy & neuropathic pain Renal impairment w/ CrCl ≥80 mL/min 900-3,600 mg/day, 50-79 mL/min 600-1,800 mg/day, 30-49 mL/min 300-900 mg/day, 15-29 mL/min 150 mg (administered as 300 mg every other day) to 600 mg/day, <15 mL/min 150 mg (administered as 300 mg every other day) to 300 mg/day. Patients undergoing hemodialysis Loading dose: 300-400 mg, then 200-300 mg following each 4 hr of hemodialysis.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Abrupt w/drawal may precipitate status epilepticus. Not for treatment of absence seizures. Concomitant use w/ opioids. Drug rash w/ eosinophilia & systemic symptoms (DRESS). Discontinue treatment if signs & symptoms of anaphylaxis occur. Evaluate patients for history of drug abuse. False positive results w/ Ames N-Multistix SG dipstick-test in concomitant use w/ other anticonvulsant drugs. May impair ability to drive & use machines. Pregnancy & lactation.
Adverse Reactions
Abdominal pain, back pain, fatigue, fever, headache, viral infection; vasodilation; constipation, dental abnormalities, diarrhea, dyspepsia, increased appetite, dry mouth or throat, nausea &/or vomiting; leukopenia, decreased WBC; peripheral edema, increased wt; fracture, myalgia; amnesia, ataxia, confusion, abnormal coordination, depression, dizziness, dysarthria, emotional lability, insomnia, nervousness, nystagmus, somnolence, abnormal thinking, tremor, twitching; coughing, pharyngitis, rhinitis; abrasion, acne, pruritus, rash; ambylopia, diplopia; impotence. Hostility, hyperkinesia; bronchitis, resp infection. Accidental injury, asthenia, flu syndrome, infection, pain; flatulence; abnormal gait, hypesthesia, vertigo, dyspnea.
Drug Interactions
Resp depression &/or sedation may occur w/ opioids. Reduced bioavailability w/ Al- & Mg-containing antacids.
MIMS Class
Anticonvulsants / Drugs for Neuropathic Pain
ATC Classification
N03AX12 - gabapentin ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Neurontin cap 100 mg
Packing/Price
100's
Form
Neurontin cap 300 mg
Packing/Price
100's;30's
Form
Neurontin cap 400 mg
Packing/Price
100's
Form
Neurontin tab 600 mg
Packing/Price
(scored) 100's
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