Neurontin Overdosage





Zuellig Pharma
Full Prescribing Info
Acute, life-threatening toxicity has not been observed with gabapentin overdoses of up to 49 g. Symptoms of the overdoses included dizziness, double vision, slurred speech, drowsiness, loss of consciousness, lethargy, and mild diarrhea. All patients recovered fully with supportive care.
Reduced absorption of gabapentin at higher doses may limit drug absorption at the time of overdosing, and hence, minimize toxicity from overdoses.
Although gabapentin can be removed by hemodialysis, based on prior experience, it is usually not required. However, in patients with severe renal impairment, hemodialysis may be indicated.
An oral lethal dose of gabapentin was not identified in mice and rats given doses as high as 8,000 mg/kg. Signs of acute toxicity in animals included ataxia, labored breathing, ptosis, hypoactivity, or excitation.
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