Neurox-250

Neurox-250

cefuroxime

Manufacturer:

Nectar Lifesciences

Distributor:

Community Pharm PCL
Concise Prescribing Info
Contents
Cefuroxime axetil
Indications/Uses
Mild to moderate infections, pharyngitis or tonsilitis; acute bacterial otitis media; acute bacterial maxilliary sinusitis; acute bacterial exacerbations of chronic bronchitis & secondary bacterial infection of acute bronchitis; uncomplicated skin & skin-structure infections; uncomplicated UTI; uncomplicated gonorrhea, urethral & endocervical; early lyme disease.
Dosage/Direction for Use
Adult & adolescents ≥13 yr Pharyngitis/tonsilitis; acute bacterial maxillary sinusitis 250 mg bid for 10 days. Acute bacterial exacerbations of chronic bronchitis; uncomplicated skin & skin-structure infections 250 or 500 mg bid for 10 days. Secondary bacterial infections of acute bronchitis 250 or 500 mg bid for 5-10 days. Uncomplicated UTI 250 mg bid for 7-10 days. Uncomplicated gonorrhea 1,000 mg as a single dose. Early lyme disease 500 mg bid for 20 days. Ped patients Acute otitis media; acute bacterial maxillary sinusitis 250 mg bid for 10 days.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
Hypersensitivity to cefuroxime axetil, other cephalosporins or penicillins & other β-lactams. Prolonged use. Concurrent treatment w/ potent diuretics. History of colitis; GI malabsorption. Pseudomembranous colitis. May decrease prothrombin activity. Renal or hepatic impairment. Patients w/ poor nutritional state, receiving a protracted course of antimicrobial therapy & previously stabilized on anticoagulant therapy. Pregnancy & lactation.
Adverse Reactions
Diarrhea, nausea, vomiting & abdominal pain. Elevated AST, transient elevation in ALT, alkaline phosphatase & LDH; decreased in Hb & hematocrit; elevation of eosinophilia, abdominal cramps, flatulence, indigestion, headache, vaginitis; vulvar itch, rash, hives, itch, dysuria, chills, chest pain, shortness of breath, mouth ulcers, swollen tongue, sleepiness, thirst, anorexia.
Drug Interactions
Increased serum conc w/ probenecid. Lower bioavailability w/ drugs that reduce gastric acidity. Increased risk of nephrotoxicity w/ aminoglycosides. Increased renal adverse effects w/ diuretics. Reduced plasma conc w/ H2-antagonists.
MIMS Class
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Neurox-250 film-coated tab
Packing/Price
1 × 10's
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