The 2 most serious adverse reactions reported in patients treated with Nirmet have been convulsive seizures and peripheral neuropathy.
The following reactions have also been reported during treatment with Nirmet: Gastrointestinal: Nausea, vomiting, abdominal discomfort, diarrhea and an unpleasant metallic taste.
Hematologic: Reversible leukopenia.
Dermatologic: Erythematous rash and pruritus.
Central Nervous System: Headache, dizziness, syncope, ataxia, and confusion.
Local Reactions: Thrombophlebitis after intravenous infusion. This reaction can be minimized or avoided by avoiding prolonged use of indwelling intravenous catheters.
Miscellaneous: Fever. Instances of darkened urine have also been reported. A furred tongue, glossitis and stomatitis have occurred; these may be associated with an overgrowth of Candida.