Norvasc

Norvasc

amlodipine

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Amlodipine besylate
Indications/Uses
1st-line treatment of HTN & used as sole agent to control BP & can be used in combination w/ thiazide diuretics, α-blockers, β-adrenoceptor blocking agent or ACE inhibitors in patients not adequately controlled on a single antihypertensive agent. Reduce risk of fatal CHD & non-fatal MI, & stroke. Reduce risk of coronary revascularization & hospitalization due to angina in patients w/ CAD. 1st-line treatment of myocardial ischaemia whether due to fixed obstruction (stable angina) &/or vasospasm/vasoconstriction (Prinzmetal's variant angina) of coronary vasculature which may be used in monotherapy or in combination w/ other antianginal drugs in patients w/ angina refractory to nitrates &/or β-blockers.
Dosage/Direction for Use
Adult HTN & angina Initially 5 mg once daily which may be increased to a max dose of 10 mg depending on patient's response. CAD 5-10 mg once daily. Childn 6-17 yr 2.5-5 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to amlodipine or dihydropyridines.
Special Precautions
NYHA class III & IV heart failure & impaired liver function. Pregnancy & lactation.
Adverse Reactions
Headache, dizziness, somnolence; palpitations, flushing, abdominal pain, nausea; oedema & fatigue.
Drug Interactions
Increase exposure of simvastatin. Bioavailability may be increased w/ grapefruit juice. May increase plasma conc w/ strong CYP3A4 inhibitors eg, ketoconazole, itraconazole, ritonavir. Increased risk of hypotension w/ clarithromycin. Plasma conc may decrease w/ CYP3A4 inducers eg, rifampicin, Hypericum perforatum. May increase trough conc of cyclosporin. Risk of increased tacrolimus blood levels. May increase exposure of mTOR inhibitors eg, sirolimus, temsirolimus & everolimus.
ATC Classification
C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Norvasc tab 10 mg
Packing/Price
30's
Form
Norvasc tab 5 mg
Packing/Price
30's
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