Cardiovascular: Aggravated hypertension, coronary artery disorder (less than 2%); aortic valve incompetence, cerebral infarction, deep vein thrombosis, sinus bradycardia, ventricular hypertrophy (less than 1%); peripheral gangrene, thrombophlebitis, ventricular fibrillation (less than 0.1%).
CNS: Ataxia, suicide (less than 0.1%); fetal intracranial hemorrhage.
Dermatologic: Cellulitis, contact dermatitis, dermatitis, dry skin, rash erythematous, rash maculopapular, skin disorder, skin nodule (less than 2%).
GI: Upper Abdominal pain (8%); gastroesophageal reflux disease (4.7%); diverticulitis, dysphagia, hemorrhoids, hepatic function abnormal, hiatal hernia, tenesmus (less than 2%); cholelithiasis, colitis with bleeding, esophageal perforation, ileus, intestinal obstruction, intestinal perforation (less than 0.1%).
GU: Ovarian cyst (less than 1%).
Lab Test Abnormalities: Alkaline phosphatase increased, creatine phosphokinase increased (less than 2%); blood potassium increased, blood sodium increased, blood testosterone decreased (less than 1%).
Metabolic/Nutritional: Hypercholesterolemia, nonprotein nitrogen increase (less than 2%); hypoglycemia, hyponatremia.
Musculoskeletal: Arthrosis, leg cramps, synovitis, tendinitis (less than 2%); epicondylitis, tendon rupture (less than 1%).
Respiratory: Nasopharyngitis (6%); bronchospasm aggravated, laryngitis (less than 2%).
Special Senses: Deafness (less than 2%); conjunctival hemorrhage, labyrinthitis, vitreous floaters (less than 1%).
Miscellaneous: Injury and poisoning (6%); allergy aggravated, cyst NOS, hot flushes, peripheral pain (less than 2%); sepsis, sudden death (less than 0.1%).