Painex Drug Interactions





Prosp Pharma
Full Prescribing Info
Drug Interactions
Metabolism/Transport Effects Substrate of CYP2C9 (major), CYP3A4 (minor).
Inhibits CYP2C8 (moderate), CYP2D6 (weak).
Avoid Concomitant Use: Avoid concomitant use of Celecoxib with any of the following: Acemetacin; Aminolevulinic Acid (Systemic); Amodiaquine; Dexibuprofen; Dexketoprofen; Floctafenine; Ketorolac (Nasal); Ketorolac (Systemic); Macimorelin; Mecamylamine; Mifamurtide; Morniflumate; Nonsteroidal Anti-inflammatory Agents; Nonsteroidal Anti-inflammatory Agents (COX-2 Selective); Omacetaxine; Pelubiprofen; Phenylbutazone; Talniflumate; Tenoxicam; Zaltoprofen.
Increased Effect/Toxicity: Celecoxib may increase the levels/effects of: 5-Aminosalicylic Acid Derivatives; Ajmaline; Aliskiren; Aminoglycosides; Aminolevulinic Acid (Systemic); Aminolevulinic Acid (Topical); Amodiaquine; Anticoagulants; Aripiprazole; Bisphosphonate Derivatives; Cyclosporine (Systemic); CYP2C8 substrates (high risk with inhibitors); Deferasirox; Desmopressin; Dexibuprofen; Digoxin; Drospirenone; Eplerenone; Estrogen Derivatives; Haloperidol; Lithium; Mecamylamine; Methotrexate; Nonsteroidal Anti-inflammatory Agents (COX-2 Selective); Omacetaxine; Perhexiline; Porfimer; Potassium-Sparing Diuretics; Pralatrexate; Prilocaine; Quinolones; Selexipag; Sodium nitrate; Tacrolimus (Systemic); Tenofovir Products; Tolperisone; Triflusal; Vancomycin; Verteporfin; Vitamin K Antagonists.
The levels/effects of celecoxib may be increased by: Acemetacin; Alcohol (Ethyl);  Angiotensin II Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Ceritinib; Corticosteroids (Systemic); Cyclosporine (Systemic); CYP2C9 inhibitors (Moderate); CYP2C9 inhibitors (Strong); Dapsone (Topical); Dexketoprofen; Felbinac; Floctafenine; Herbs (Anticoaguiant/Antiplatelet Properties); Ketorolac (Nasal); Ketorolac (Systemic); Loop Diuretics; Lumacaftor; Mifepristone; Morniflumate; Naftazone; Nitric Oxide; Nonsteroidal Anti-inflammatory Agents; Pelubiprofen; Phenylbutazone; Probenecid; Selective Serotonin Reuptake Inhibitors; Sodium Phosphates; Talniflumate; Tenoxicam; Tetracaine (Topical); Thiazide and Thiazide-Like Diuretics; Tolperisone; Tricyclic Antidepressants (Tertiary Amine); Triflusal; Zaltoprofen.
Decreased Effect: Celecoxib may decrease the levels/effects of: Aliskiren; Angiotensin II Receptor Blockers; Angiotensin­-Converting Enzyme Inhibitors; Beta-Blockers; Eplerenone; Hydralazine; Loop Diuretics; Macimorelin; Mifamurtide; Potassium-Sparing Diuretics; Prostaglandins (Ophthalmic); Selective Serotonin Reuptake Inhibitors; Thiazide and Thiazide-Like Diuretics.
The levels/effects of Celecoxib may be decreased by: Bile Acid Sequestrants; CYP2C9 Inducers (Moderate); Dabrafenib; Enzalutamide; Lumacaftor; Rifapentine.
Food Interactions: Peak concentrations are delayed and AUC is increased by 10% to 20% when taken with a high fat meal.
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