Limited information is available on the acute toxicity of celecoxib in humans. Serious toxicity was not observed in 12 individuals who received celecoxib 2.4 g daily for 10 days.
Manifestations: Overdosage of NSAIDs (nonsteroidal anti-inflammatory agents) can cause lethargy, drowsiness, nausea, vomiting, and epigastric pain; these manifestations generally are reversible with supportive care. GI bleeding also has been reported. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Anaphylactoid reactions have been reported with therapeutic use of NSAIDs and may occur following an overdosage.
Treatment: Treatment of NSAIDs overdosage involves symptomatic and supportive care; there is no specific antidote for NSAIDs overdosage. During the first 4 hours after overdosage, emesis and/or administration of activated charcoal (60-100 g in adults or 1-2 g/kg in children) and/or an osmotic cathartic may be useful in symptomatic patients or in those who reportedly ingested a large overdosage. It is not known whether celecoxib is removed by hemodialysis, but the drug's extensive protein binding suggests that forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion is likely to be ineffective in removing substantial amounts of celecoxib from the body.