Pregnancy: Category C (less than 30 weeks' gestation).
Category D (starting at 30 weeks' gestation).
NSAIDs may cause premature closure of the ductus arteriosus, celecoxib should be avoided starting at 30-weeks gestation.
Celecoxib is a NSAID that primarily inhibits COX-2 whereas other available NSAIDs are nonselective for COX-1 and COX-2. The effects of this selective inhibition to the fetus have not been well studied and limited information is available specific to celecoxib.
Lactation: Celecoxib is present in breast milk. Most NSAIDs are excreted in breast milk. In general, do not use in breast-feeding mothers because of the possible adverse effects of prostaglandin-inhibiting drugs on neonates.