Significant: Infusion reactions (e.g. fever, chills, hypotension), photosensitivity, dermatologic toxicities (e.g. erythema, pruritus, rash, dry skin, skin fissures, skin exfoliation, acneiform dermatitis, paronychia, local abscesses), electrolyte depletion (e.g. hypomagnesemia, hypokalaemia , keratitis or ulcerative keratitis.
Blood and lymphatic system disorders: Anaemia, leucopenia.
Cardiac disorders: Tachycardia.
Eye disorders: Abnormal eyelashes growth, blepharitis, dry eye, eye pruritus or irritation, conjunctivitis.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, constipation, dyspepsia, GERD, abdominal pain, rectal haemorrhage, dry mouth, cheilitis, stomatitis or aphthous ulcer.
General disorders and administration site conditions: Fatigue, weakness, asthenia, pyrexia, chills, mucosal inflammation, peripheral oedema, pain.
Immune system disorders: Hypersensitivity reactions, antibody formation.
Infections and infestations: Folliculitis, cellulitis, localised infection, paronychia.
Investigations: Decreased weight.
Metabolism and nutrition disorders: Decreased appetite, dehydration, hyperglycaemia, hypocalcaemia, hypophosphataemia, hypokalaemia.
Musculoskeletal and connective tissue disorders: Back pain, pain in extremity.
Nervous system disorders: Headache, dizziness.
Psychiatric disorders: Insomnia, anxiety.
Renal and urinary disorders: UTI.
Respiratory, thoracic and mediastinal disorders: Cough, dyspnoea, pulmonary embolism, epistaxis.
Skin and subcutaneous tissue disorders: Alopecia, hypertrichosis, hyperhidrosis, palmar-plantar erythrodysaesthesia syndrome, skin ulcer, nail disorder (e.g. onychoclasis).
Vascular disorders: Flushing, hypertension, deep vein thrombosis.
Potentially Fatal: Severe dermatological toxicities (e.g. necrotising fasciitis, sepsis, Stevens-Johnson syndrome, toxic epidermal necrolysis), severe diarrhoea, dehydration. Rarely, bullous mucocutaneous disease, infusion-related toxicities (e.g. bronchospasm, hypotension, angioedema, anaphylaxis), interstitial lung disease, pulmonary fibrosis.