IV Duodenal & gastric ulcer, moderate & severe reflux esophagitis
Recommended dose: 40 mg/day. Long-term management of Zollinger-Ellison syndrome & other hypersecretory conditions
Initially 80 mg daily, thereafter, dosage can be titrated up or down as needed using measurements of gastric acid secretion to guide. Doses >80 mg daily, should be given in 2 divided doses daily. Rapid acid control
Initially 2 x 80 mg to decrease acid output into the target range (<10 mEq/hr) w/in 1 hr.