Pasireotide is used to treat acromegaly, a disorder caused by excessive production of growth hormone by the pituitary gland and is characterised by progressive enlargement of the hands, feet, and face.
Pasireotide is to be given by deep intramuscular (into the muscle) injection. Your doctor or nurse will administer the injection for you.
It may be necessary for you to take this medicine for a long time, such as for a few years. Your doctor will advise you on the treatment timeframe.
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Pasireotide.
If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
Alert your doctor if you have severe liver disease as Pasireotide may not be suitable for you.
Inform your doctor if you have the following conditions:
- heart disease e.g. irregular (fast/slow) heartbeat, heart block, heart failure, unstable chest pain
- low levels of potassium or magnesium in your blood
- severe kidney disease
Let your doctor know if you are pregnant or breastfeeding.
If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. Your doctor may also need to perform tests (e.g. liver function test, ECG or electrocardiogram, blood sugar level, gallbladder imaging, pituitary function test) before you use Pasireotide and thereafter depending on your doctor’s advice.
Pasireotide may cause tiredness, weakness, and dizziness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: headache, diarrhoea, nausea, stomach pain, vomiting, decreased appetite, anxiety, difficulty sleeping, flu, muscle pain, dry skin, itching, hair loss, and swelling of the ankles, feet, or hands.
You may also experience redness, itching, pain, swelling, bruising, or a small amount of blood loss at the injection site.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- rashes, breathlessness, swelling of the mouth, face, lips, tongue, or throat
- frequent urination, increased thirst, blurred vision
- yellowing of the skin or eyes
- sudden pain in the upper right stomach area, fever with chills
- darkening of skin, severe tiredness, unintentional weight loss, muscle or joint pain, salt craving, lightheadedness or fainting
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking any of these medicines:
- medicines for irregular heartbeat e.g. quinidine, procainamide, disopyramide, amiodarone, sotalol
- certain antibiotics e.g. clarithromycin, moxifloxacin
- medicines for mental illness or mood disorders e.g. chlorpromazine, thioridazine, pimozide, haloperidol, amisulpride, sertindole
- medicines for cold or allergy e.g. terfenadine, astemizole
- medicines for malaria e.g. chloroquine, halofantrine, lumefantrine
- medicines for fungal infection e.g. ketoconazole
- medicines for high blood pressure e.g. metoprolol, propranolol, verapamil, diltiazem
- medicines for Parkinson’s disease (a brain disease that affects movement) e.g. rivastigmine
- medicines for diabetes e.g. insulin, metformin
This list does not include all medicines that may interact with Pasireotide.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in the refrigerator, between 2-8°C. Do not allow to freeze. If frozen, this medicine will become ineffective and should not be used. Protect from light.
Do not use this medicine if it becomes cloudy or if it has changed in colour. Medicines must not be used past the expiry date.