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Penthrox

Penthrox

Manufacturer:

Daiichi Sankyo

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Methoxyflurane
Indications/Uses
Emergency relief of moderate to severe pain in conscious adult patients w/ trauma & associated pain.
Dosage/Direction for Use
3 mL to be vaporised in an inhaler. Max: 6 mL in a single administration. Inhale intermittently to achieve adequate analgesia. Total dose in a wk: 15 mL.
Contraindications
Hypersensitivity to Penthrox or any fluorinated anaesth. Known genetic susceptibility to malignant hyperthermia or family history of severe drug reactions to inhaled anaesth. History of signs of liver damage after previous methoxyflurane use or halothane anaesth. Clinically evident CV instability, resp depression. Altered level of consciousness. Clinically significant renal impairment. Use as an anaesth agent.
Special Precautions
Nephrotoxicity. Do not administer in patients showing signs of liver damage, especially after previous methoxyflurane or halothane anaesth; w/ underlying hepatic conditions or w/ risks for hepatic dysfunction. Potential effects on BP & heart rate, & CNS. Occupational exposure. Not to be used for relief of break-through pain/exacerbations in chronic pain conditions & trauma related pain in closely related episodes for the same patient. Caution as Penthrox contains butylated hydroxytoluene. May have a minor influence on the ability to drive or operate machinery. Pregnancy especially during 1st trimester. Lactation. Elderly w/ hypotension & bradycardia.
Adverse Reactions
Dizziness. Euphoric mood; amnesia, dysarthria, dysgeusia, headache, somnolence; hypotension; cough; dry mouth, nausea; feeling drunk.
Drug Interactions
Potential toxicity may be increased by CYP 2E1 (eg, alcohol, INH) & CYP 2A6 (eg, phenobarb, rifampicin) enzyme inducers. Additive depressant effects w/ CNS depressants eg, opioids. Additive effect on nephrotoxicity w/ medicines (eg, antibiotics) known to have nephrotoxic effect eg, tetracycline, gentamicin, colistin, polymyxin B & amphotericin B. Serum fluoride levels & nephrotoxicity may be increased w/ sevoflurane. 
ATC Classification
N02BG09 - methoxyflurane ; Belongs to the class of other analgesics and antipyretics.
Presentation/Packing
Form
Penthrox inhalation liqd 99.9%
Packing/Price
(w/ inhaler w/ AC chamber) 3 mL x 1's
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