Phenobarbitone GPO

Phenobarbitone GPO

phenobarbital

Manufacturer:

GPO

Distributor:

GPO
Concise Prescribing Info
Contents
Phenobarb
Indications/Uses
Epilepsy, bilirubin blood level reduction in hyperbilirubinemia.
Dosage/Direction for Use
Epilepsy Adult 60-250 mg once daily or in divided doses. Childn 1-6 mg/kg once daily or in divided doses. Hyperbilirubinemia Adult 30-60 mg tid. Childn <12 yr 1-4 mg/kg tid. Newborn 5-10 mg/kg daily.
Contraindications
Hypersensitivity to barbiturates. Patients w/ porphyria or severe resp disorders. Concomitant use w/ CNS depressants, alcohol consumption, or alcohol-containing products.
Special Precautions
Discontinue use if hypersensitivity or serious adverse drug reaction, & in case of abnormality eg, fever, sore throat, infection, abnormal bleeding occurs. History of epileptic drug allergy (eg, carbamazepine, phenytoin). Do not use for long-term treatment. Regularly assess treatment outcome & gradually decrease dose. Avoid abrupt w/drawal. Liver or renal impairment, resp disorders, depression, drug abusers. Paradoxical effects in childn & elderly. Monitor blood profile in chronic use. Concomitant use w/ barbiturates. Do not drive or operate machinery or take hazardous activity during therapy. Pregnancy & lactation.
Adverse Reactions
Stevens-Johnson syndrome, drug-induced hypersensitivity  (eg, fever, rash, lymphadenopathy, hepatitis, myocardial, pulmonary or renal disorders, arthritis, leukopenia); osteopenia, rickets or drug addiction (chronic use); depression especially in elderly or weak patients.
Drug Interactions
Increased CNS depression leading to drowsiness & resp depression w/ CNS depressants or alcohol consumption. Decrease blood conc of corticosteroids, chloramphenicol, cyclosporin, metronidazole, quinidine, coumarin, carbamazepine, oxcarbamazepine, theophylline, digitoxin, or OCs. Decrease absorption of griseofulvin. Decreased liver metabolism w/ MAOIs.
ATC Classification
N03AA02 - phenobarbital ; Belongs to the class of barbiturates and derivatives antiepileptics.
Presentation/Packing
Form
Phenobarbitone GPO tab 60 mg
Packing/Price
1000's
Form
Phenobarbitone GPO tab 30 mg
Packing/Price
1000's
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