Phenylephrine HCl Aguettant

Phenylephrine HCl Aguettant

phenylephrine

Manufacturer:

Aguettant

Distributor:

Indochina Healthcare
Concise Prescribing Info
Contents
Phenylephrine HCl
Indications/Uses
Hypotension during spinal, epidural or general anesth.
Dosage/Direction for Use
Adult IV bolus inj: 50-100 mcg. May be repeated until desired effect is attained. Max: 100 mcg. Continuous infusion: Initially 25-50 mcg/min. May be increased or decreased to maintain the systolic BP close to normal value.
Contraindications
Hypersensitivity. Severe HTN or peripheral vascular disease due to risk of ischemic gangrene or vascular thrombosis. In combination w/ non-selective MAOIs (or w/in 2 wk of their w/drawal) due to risk of paroxysmal HTN & possibly fatal hyperthermia. Severe hyperthyroidism.
Special Precautions
Monitor arterial BP during treatment. Patients w/ DM, arterial HTN, uncontrolled hyperthyroidism, CHD & chronic heart conditions, non-severe peripheral vascular insufficiency, bradycardia, partial heart block, tachycardia, arrhythmias, angina pectoris, aneurysma, closed angle glaucoma; arteriosclerosis, impaired cerebral or coronary circulation; serious heart failure or cardiogenic shock; controlled Na diet. Closely monitor vital organ functions in patients w/ reduced cardiac output or coronary vascular disease & consider dose reduction when systemic BP nears lower end of the target range. Avoid extravasation. Pregnancy. Elderly.
Adverse Reactions
Bradycardia, hypertensive episodes, nausea & vomiting.
Drug Interactions
Paroxysmal HTN & hyperthermia w/ non-selective MAOIs eg, iproniazid, nialamide. Risk of vasoconstriction &/or hypertensive crisis w/ dopaminergic ergot alkaloids eg, bromocriptine, cabergoline, lisuride, pergolide; vasoconstrictor ergot alkaloids eg, dihydroergotamine, ergotamine, methylergometrine, methylsergide; selective type A MAOIs eg, moclobemide, toloxatone; linezolid. Paroxysmal HTN w/ arrhythmia w/ TCAs eg, imipramine; noradrenergic-serotoninergic antidepressants eg, minalcipram, venlafaxine; sibutramine. Increased BP w/ guanethidine. Increased risk of arrhythmias w/ cardiac glycosides, quinidine. Risk of perioperative hypertensive crisis & arrhythmia w/ halogenated volatile anaesth eg, desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane. Severe persistent HTN may occur w/ oxytocic agents.
MIMS Class
Vasoconstrictors
ATC Classification
C01CA06 - phenylephrine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of hypotension.
Presentation/Packing
Form
Phenylephrine HCl Aguettant inj 50 mcg/mL
Packing/Price
10 mL x 10 × 1's
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