Picoprep

Picoprep

Manufacturer:

Ferring

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Na picosulfate monohydrate 10 mg, light Mg oxide 3.5 g, anhydrous citric acid 12 g
Indications/Uses
Clean the bowel prior to X-ray exam, endoscopy or surgery when clinically necessary.
Dosage/Direction for Use
Adult including the elderly, childn ≥9 yr Split-dose regimen (evening before & day of the procedure) 1st sachet is taken the night before the procedure & 2nd is taken the next day, in the morning prior to the procedure. Day before the procedure: 1st reconstituted sachet is taken in the evening followed by at least five 250-mL clear liqd drinks. Day of the procedure: 2nd reconstituted sachet is taken in the morning (5-9 hr before the procedure) followed by at least three 250-mL clear liqd drinks. Clear liqd may be consumed until 2 hr before the procedure. Day-before regimen (evening before the procedure only) 1st sachet is taken in the afternoon or early evening & 2nd is taken approx 6 hr later, the night before the procedure. Day before the procedure: 1st reconstituted sachet is taken in the afternoon or early evening followed by at least five 250-mL clear liqd drinks. 2nd reconstituted sachet is taken in the late evening followed by at least three 250-mL clear liqd drinks consumed until 2 hr before the procedure. Childn 4-9 yr 1 sachet morning, ½ sachet afternoon, 2-4 yr ½ sachet morning & afternoon, 1-2 yr ¼ sachet morning & afternoon. To be taken before 8:00 am on the day before the procedure followed by 2nd dose 6-8 hr later.
Administration
Should be taken on an empty stomach.
Contraindications
Hypersensitivity. Congestive cardiac failure, gastric retention, GI ulceration, toxic colitis, toxic megacolon, ileus, nausea & vomiting, acute surgical abdominal conditions (eg, acute appendicitis), known or suspected GI obstruction or perforation, severe dehydration, rhabdomyolysis, hypermagnesemia, active inflammatory bowel disease, severe reduced renal function.
Special Precautions
Bowel surgery. Patients w/ recent GI surgery, renal impairment, heart or inflammatory bowel disease. Concomitant use w/ drugs that may affect water &/or electrolyte balance eg, diuretics, corticosteroids & lithium. Ensure adequate oral intake of water & electrolytes particularly in less fit patients, childn, elderly, debilitated & those at risk of hypokalemia or hyponatremia. Patients on antiepileptics, w/ previously controlled epilepsy; reduced kidney function or those on a controlled K diet. Period of bowel cleansing should not be >24 hr. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Do not use as a routine laxative. Pregnancy & lactation.
Adverse Reactions
Drug Interactions
May affect absorption of antiepileptics, contraceptives, antidiabetics & antibiotics. Chelation w/ Mg w/ tetracycline & fluoroquinolone, Fe, digoxin, chlorpromazine & penicillamine if not taken at least 2 hr before & not <6 hr after administration of Picoprep. Reduced efficacy w/ bulk-forming laxatives. Increased risk of hypokalemia w/ diuretics, corticosteroids or cardiac glycosides; water retention &/or electrolyte imbalance w/ NSAIDs, drugs known to induce SIADH eg, TCAs, SSRIs, antipsychotic drugs & carbamazepine.
ATC Classification
A06AB58 - sodium picosulfate, combinations ; Belongs to the class of contact laxatives.
Presentation/Packing
Form
Picoprep powd for oral soln
Packing/Price
16.1 g x 2 × 1's
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