Severe renal impairment (GFR <30 mL/min). Perform liver function test prior to initiation of therapy & periodically thereafter. Reduce or discontinue if increases in AST or ALT conc exceeds 3x ULN ranges. Alcoholics. Advanced age, renal impairment, hypothyroidism & concomitant use of particular antilipemic agents (ie, fibric acid derivatives & niacin) are predisposing factors of myopathy & rhabdomyolysis. Discontinue if serum creatine kinase level increases.