The usual dosage for an adult is 1-2 mg of pitavastatin calcium once daily after an evening meal. The dosage may be adjusted according to the patient's age and symptoms. When lowering of the LDL cholesterol level is insufficient, the dosage may be increased to a maximum of 4 mg per day.
Precautions relate to Dosage and Administration: In the case of administration to patients with hepatic disorders, the starting dose should be set to 1 mg per day and the maximal dose should be 2 mg per day (see Precautions and Pharmacology: Pharmacokinetics under Actions).
In the case of an increase in dosage of this drug, rhabdomyolysis-related adverse events may occur, When the dosage is increased to 4 mg some attention should be given to early signs of rhabdomyolysis such as CK (CPK) elevation, myoglobinuria, myalgia and weakness. (In overseas clinical studies, doses of 8 mg or above were discontinued due to several cases of rhabdomyolysis and related adverse events.)