Do not use the drug in pregnant and breast-feeding women.
Do not use the drug in patients with liver disease.
If there is myalgia at calf, back or whole body, stop taking drug and consult physician.
Liver function tests should be performed before taking drug and 6 and 12 weeks after taking drug. For patients who routinely use the drug, liver function tests should be performed every 6 months or as recommended by a physician. If the transaminase level is greater than three times of upper normal limit, stop taking drug and consult physician.
Use with caution with digoxin, warfarin because the level of these drug in blood maybe high and became dangerous.
The risk of myopathy/rhabdomyolysis will increase when administer the drug with other following drugs. e.g. azole antifungals such as ketoconazole, itraconazole; macrolides such as erythromycin, clarithromycin; HIV protease inhibitors such as indinavir, ritonavir, nelfinavir, saquinavir; verapamil; diltiazem; gemfibrozil; nicotinic acid; cyclosporine; amiodarone.
The risk of rhabdomyolysis will increase under the following conditions e.g. use at high dose, the elderly; patients with hepatic/renal insufficiency; alcoholism; patients with hypothyroidism.
Use with caution with colchicines, especially in elderly or patients with hepatic/ renal insufficiency because there is risk of myopathy or rhabdomyolysis.
The drug using is possible to increase blood sugar level.