Plaquenil

Plaquenil

hydroxychloroquine

Manufacturer:

Sanofi-Aventis

Distributor:

DKSH
Concise Prescribing Info
Contents
Hydroxychloroquine sulphate
Indications/Uses
RA, juvenile chronic arthritis, discoid or SLE & dermatological conditions caused or aggravated by sunlight.
Dosage/Direction for Use
Adult & elderly 400 mg daily in divided doses, may be reduced to 200 mg. Max: 6.5 mg/kg/day. Childn Use min effective dose. Max: 6.5 mg/kg/day. 200-mg tab is not suitable for childn <31 kg.
Administration
Should be taken with food.
Contraindications
Preexisting maculopathy, known hypersensitivity to 4-aminoquinoline compd. Pregnancy, childn <6 yr.
Special Precautions
Retinopathy, hepatic or renal disease or concomitant use w/ drugs affecting these organs. Quinine sensitivity; GI, neurological, blood disorders; G6PD deficiency, porphyria, cutanea tarda, psoriasis. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Carry out ophthalmological exam before initiating treatment & repeat at least every 12 mth. Long-term therapy (perform periodic exam of skeletal muscle function & tendon reflexes), severe hypoglycemia, cardiomyopathy resulting in cardiac failure. May impair ability to drive or operate machinery. Childn sensitivity. Lactation.
Adverse Reactions
Blurring of vision, retinopathy, corneal changes, blurred vision, skin reactions, bleaching of hair, alopecia, GIT & CNS disturbances, skeletal muscle myopathy or neuromyopathy, cardiomyopathy, anorexia.
Drug Interactions
Aminoglycosides, cimetidine, neostigmine, pyridostigmine. Increases plasma digoxin levels. Reduced absorption if taken w/ antacids (take w/ 4-hr intervals). Enhances effects of hypoglycaemic treatment.
ATC Classification
P01BA02 - hydroxychloroquine ; Belongs to the class of aminoquinoline antimalarials.
Presentation/Packing
Form
Plaquenil tab 200 mg
Packing/Price
10 × 10's
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