Posaconazole is used to prevent and treat fungal infections.
This medicine may be used to treat other conditions as decided by your doctor.
Take Posaconazole exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Take it together with food or immediately after a meal. If you are unable to take a full meal, you may take the oral suspension with a liquid nutritional supplement or an acidic carbonated beverage (e.g. ginger ale). Try to take it at the same time each day.
This medicine is available as a tablet or as an oral suspension.
If you are taking the modified-release type of tablet (usually labeled as “ER”), swallow it whole. Do not divide, chew or crush the tablet.
If you are taking an oral suspension, shake the bottle well before you take it to ensure that the liquid is evenly mixed. Use the measuring spoon provided to measure your dose. Rinse the measuring spoon with water after administration and before storage.
There is a specific dosage recommendation for each formulation of this medicine. Tablets and oral suspension cannot be substituted for each other. Ask your doctor or pharmacist before you switch between taking a tablet or an oral suspension.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your infection.
Posaconazole must be taken regularly for it to be effective. Continue using this medicine even when you feel better. Complete the entire course of medicine. Do not stop using it unless instructed by the doctor.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to use your medicine, let your doctor and pharmacist know.
Do not take this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Posaconazole.
Do not take Posaconazole with medicines to treat migraine, heart disease, high cholesterol level, allergy, stomach problems, mental disorder and malaria. Please see the section “Can I take this with other medicines?” below for more information.
Inform your doctor if you have the following conditions:
- heart disease e.g. heart rhythm disorder, heart muscle disease
- liver disease
- kidney disease
- body weight of more than 120 kg or less than 60 kg
Let your doctor know if you are pregnant or breastfeeding.
If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. Your doctor may also need to do routine blood tests (e.g. liver function tests, kidney function tests, complete blood count, and levels of calcium, magnesium, potassium in the blood) before and during treatment with this medicine.
Posaconazole may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: headache, diarrhoea, nausea, vomiting, stomach pain or discomfort, constipation, loss of appetite, fever, back pain, weakness, difficulty sleeping, chills, mouth sores, rash, itching, and muscle and joint pain.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- rashes, breathlessness, swollen mouth or eyes
- frequent and persistent sore throat with fever, unusual bleeding or bruising
- abnormal heart rhythm, muscle spasms
- abnormal eye movements, convulsions
- increased thirst, frequent urination, blurred vision, trouble concentrating
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take this medicine with the following medicines:
- medicines for migraine e.g. ergotamine, dihydroergotamine
- medicines for heart disease e.g. quinidine
- cholesterol-lowering medicines e.g. simvastatin, lovastatin, atorvastatin
- medicines to treat allergy e.g. terfenadine, astemizole
- stomach medicines e.g. cisapride
- medicines to treat mental disorder e.g. pimozide
- medicines to treat malaria e.g. halofantrine
Inform your doctor and pharmacist if you are taking any of these medicines:
- other medicines for heart disease e.g. digoxin, diltiazem, nifedipine, verapamil
- other stomach medicines e.g. cimetidine, esomeprazole
- medicines used in organ transplant or certain immune disorders e.g. ciclosporin, sirolimus, tacrolimus
- medicines for epilepsy (fits or seizure) e.g. phenytoin
- medicines used to treat cancer e.g. vinca alkaloids such as vincristine, vinblastine
- medicines for HIV infection e.g. atazanavir, efavirenz, fosamprenavir, ritonavir
- medicines to treat TB (infection known as tuberculosis) e.g. rifampicin
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.