Prepenem Dosage & Drug Information

Concise Prescribing Info

Contents

Imipenem 500 mg, cilastatin Na 500 mg

Indications/Uses

Intra-abdominal, lower resp tract, UTI, gynecological, bone & joint, skin & skin structure infections, bacterial septicemia, endocarditis & polymicrobic infections. May be used as empiric therapy.

Dosage/Direction for Use

IV infusion Adult 1-2 g/day in divided doses 6 or 8 hrly, may be increased to 3-4 g/day. Max daily dose: 50 mg/kg/day or 4 g/day. Infusion rate: 250 or 500 mg doses over 20-30 min & 750 or 1,000 mg doses over 40-60 min. Renal insufficiency ≤2 g/day. Ped ≥3 mth 15-25 mg/kg/dose 6 hrly.

Contraindications

Hypersensitivity.

Special Precautions

Dose adjustment in patients w/ renal impairment or CNS disorders. Hypersensitivity to β-lactams. Pregnancy & lactation, childn <30 kg w/ impaired renal function.

Adverse Reactions

GI disturbances, rash, urticaria, pruritus, erythema, pseudomembranous colitis, hematological disturbances, myoclonus, confusion, seizures, psychic disturbances, paresthesia, hearing loss, taste perversion, acute renal failure, oliguria/anuria, polyuria.

View ADR Monitoring Form

Drug Interactions

Ganciclovir.

MIMS Class

Other Beta-Lactams

ATC Classification

J01DH51 - imipenem and cilastatin ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.

Thai FDA Category

Presentation/Packing

Form

Prepenem powd for inj

Packing/Price

10 × 1's

Prepenem

imipenem + cilastatin

Manufacturer:

JW Pharmaceutical

Distributor:

Siam Pharmaceutical