Priftin

Priftin

rifapentine

Manufacturer:

Sanofi-Aventis

Distributor:

DKSH
Concise Prescribing Info
Contents
Rifapentine
Indications/Uses
Latent TB infection caused by Mycobacterium tuberculosis in adults & childn ≥2 yr who are at high risk of progression to TB always in combination w/ INH.
Dosage/Direction for Use
Wt based dose. >50 kg 900 mg once wkly, 32.1-50 kg 750 mg once wkly, 25.1-32 kg 600 mg once wkly, 14.1-25 kg 450 mg once wkly, 10-14 kg 300 mg once wkly. Adult & childn ≥ 12 yr INH recommended dose: 15 mg/kg. Max: 900 mg once wkly for 12 wk. Childn 2-11 yr INH recommended dose: 25 mg/kg. Max: 900 mg once wkly for 12 wk.
Administration
Should be taken with food: Take w/ food to minimise GI discomfort. For patients unable to swallow, crush & add tab to a small amount semi-solid food & consume immediately.
Contraindications
Hypersensitivity to rifapentine or any other rifamycins eg, rifampicin & rifabutin.
Special Precautions
May cause serious hepatic reaction. Patients w/ abnormal liver tests &/or liver disease. Carefully monitor liver parameters (serum transaminases & bilirubin) prior to therapy & then every 2-4 wk during therapy. Discontinue treatment if liver reaction, pseudomembranous colitis occurs or hepatic conditions worsens. Monitor for hypersensitivity reactions & discontinue treatment if occurs. Concomitant use w/ other antituberculosis drugs that may cause hepatotoxicity (eg, INH, pyrazinamide); CYP3A4 & CYP2C8/9 inducers eg, PI, reverse transcriptase inhibitors & hormonal contraception; digoxin. C. difficile-associated diarrhea. May permanently stain contact lenses or dentures & produce predominantly red-orange discoloration of body tissues &/or fluids. Patients w/ porphyria. Pregnancy & lactation. Perform coagulation testing during late pregnancy. Therapeutic conc of rifampin may inhibit standard microbiological assays for serum folate & vit B12.
Adverse Reactions
Drug Interactions
May increase metabolism of other drugs metabolized by CYP3A4 & CYP2C8/9. May modify plasma exposure of digoxin. Decrease plasma conc of PI & certain reverse transcriptase inhibitors. May reduce effectiveness of hormonal contraceptives. May cause drug displacement interactions w/ NSAIDs, sulfonylureas & oral anticoagulants.
MIMS Class
Anti-TB Agents
ATC Classification
J04AB05 - rifapentine ; Belongs to the class of antibiotics. Used in the systemic treatment of tuberculosis.
Presentation/Packing
Form
Priftin FC tab 150 mg
Packing/Price
24's
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