Priftin

Priftin Dosage/Direction for Use

rifapentine

Manufacturer:

Sanofi-Aventis

Distributor:

DKSH
Full Prescribing Info
Dosage/Direction for Use
Priftin should be administered once-weekly in combination with isoniazid for 12 weeks as directly observed therapy.
Adults and children 12 years and older: The recommended dose of Priftin should be determined based on weight of the patient up to a maximum of 900 mg once-weekly (see Table 7). The recommended dose of isoniazid is 15 mg/kg (rounded to the nearest 50 mg or 100 mg) up to a maximum of 900 mg once-weekly for 12 weeks.
Children 2 - 11 years: The recommended dose of Priftin should be determined based on weight of the patient up to a maximum of 900 mg once-weekly (see Table 7). The recommended dose of isoniazid is 25 mg/kg (rounded to the nearest 50 mg or 100 mg) up to a maximum of 900 mg once-weekly for 12 weeks.

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Special Populations: Pediatric patients: The youngest patient included in the clinical efficacy trial was 2 years. No data are available for patients below 2 years old.
Elderly patients: No dose adjustment required.
Hepatic impairment: No dose adjustment required.
Renal impairment: No dose adjustment required.
Patients should be informed that adherence to the treatment regimen for rifapentine and other substances is essential for effective treatment, and the importance of not missing any doses must be stressed.
Priftin should be given with food. For patients with a propensity to nausea, vomiting or gastrointestinal upset, administration with food may be even useful.
For patients who cannot swallow tablets, the tablets may be crushed and added to a small amount of semi-solid food, all of which should be consumed immediately (see Pharmacology: Pharmacokinetics under Actions). Interactions with antacids have not been studied. However, in the clinical efficacy study, patients were advised to take Priftin at least 1 hour before or 2 hours after the ingestion of antacids.
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