Priftin Overdosage





Full Prescribing Info
Signs and Symptoms: No case of an acute overdose with Priftin has been reported.
In pharmacokinetic trials, eight healthy male volunteers were given single oral doses of Priftin up to 1200 mg. Adverse events were mild and well tolerated (mainly headache and gastrointestinal upset).
Out of 32 patients (20 to 74 years) who accidentally received continuous daily doses of 600 mg rifapentine for up to 20 days, one patient experienced a transient elevation in SGPT and glucose and a second patient experienced slight pruritus.
Management: While there is no experience in the treatment of overdose with Priftin, clinical experience with rifamycins suggest that gastric lavage to evacuate gastric contents (within a few hours of overdose), followed by instillation of an activated charcoal slurry into the stomach, may help adsorb any remaining drug from the gastrointestinal tract.
Rifapentine and 25-desacetyl rifapentine are highly plasma protein bound and have limited urinary excretion. Therefore, neither hemodialysis nor forced diuresis is expected to enhance the systemic elimination.
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