Priftin Special Precautions





Full Prescribing Info
Special Precautions
Clostridium difficile-associated diarrhea: Pseudomembranous colitis has been reported to occur with various antibiotics, including other rifamycins. Diarrhea, particularly if severe and/or persistent, occurring during treatment or in the initial weeks following treatment may be symptomatic of Clostridium difficile-associated disease, the most severe form of which is pseudomembranous colitis. If pseudomembranous colitis is suspected, Priftin should be stopped immediately and the patient treated appropriately without delay. Medications inhibiting the peristalsis are contraindicated in this clinical situation.
Discoloration of body fluids: Priftin may produce a predominantly red-orange discoloration of body tissues and/or fluids (e.g., skin, teeth, tongue, urine, feces, saliva, sputum, tears, sweat, and cerebrospinal fluid).
Contact lenses or dentures may become permanently stained.
Porphyria: Porphyria has been reported in patients receiving rifampicin, attributed to induction of delta amino levulinic acid synthetase. Because Priftin may have similar enzyme induction properties, avoid the use of Priftin in patients with porphyria.
Effects on Ability to Drive and Use Machine: No information in this section.
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